Organ donor shortage has been a prevalent issue in the Philippines, with the demand that overarches the donors up until the present times. This also posed a socio-economic risk with the organ trading black markets still prevalent in the country. These associated problems have the capacity to be eradicated through tissue engineering, where the donor requirement will be eliminated and, as the technology pipeline develops, reduce the overall cost of medical care for transplantation. The ability to regenerate organs for replacement will remove the costs associated for donor matching tests and post-surgical medications for compatibility. With the current study, patients with tracheal-related pathologies could now have an option for transplantation, as tracheal donors have proven to be difficult to obtain. This study will be used as a platform for diversifying organ regeneration researches, pipelined from simple to complex organs such as kidney and heart to meet society’s need for advanced medical care.